Chemical Properties:
Package: Fluorinated Bottle, 25kg/ Drum, or according to customer's requirement Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moistureRuifu Chemical Supply Intermediates of Afatinib Afatinib CAS 439081-18-2 Afatinib Dimaleate CAS 850140-73-7 (S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2 (Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6 trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Diethylphosphonoacetic Acid CAS 3095-95-2 7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3 7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine CAS 314771-76-1 (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine CAS 314771-88-5| Item | Specifications |
| Appearance | Colorless Liquid |
| Identification (HPLC) | The retention time of the main peak obtained from the sample is within 5% of the reference sample. |
| Purity / Analysis Method | >99.5% (HPLC) |
| Infrared Spectrum | Conforms to Structure |
| Proton NMR Spectrum | Conforms to Structure |
| Moisture (K.F) | <0.50% |
| Total Impurities | <0.50% |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Afatinib Dimaleate (CAS: 850140-73-7) |
Description:
Specifications:
Package & Storage:
| Chemical Name | Diethylphosphonoacetic Acid |
| Synonyms | 2-(Diethoxyphosphoryl)acetic Acid; (Diethoxyphosphinyl)acetic Acid; Diethyl Carboxymethylphosphonate; NSC 272281 |
| CAS Number | 3095-95-2 |
| CAT Number | RF-PI2024 |
| Stock Status | In Stock, Production Capacity 30MT/Month |
| Molecular Formula | (C2H5O)2P(O)CH2CO2H |
| Molecular Weight | 196.14 |
| Boiling Point | 150℃/0.05 mmHg (lit.) |
| Density | 1.220 g/mL at 25℃ (lit.) |
| Refractive Index | n20/D 1.445 (lit.) |
| Brand | Ruifu Chemical |
Advantages:
FAQ:
Application:
Diethylphosphonoacetic Acid (CAS: 3095-95-2), Acts as a nucleophile for nucleophilic addition reactions for synthesis of allene epoxides Reactant for: Stereoselectivity studies of the Staudinger reaction; Enantioselective formation of diols via epoxidation and hydration reactions; Horner-Wadsworth-Emmons reactions; Remote chelation controlled Ireland-Claisen rearrangement; Ugi-Dieckmann reactions for synthesis of tetramic acid derivatives; Used to make phosphonoester intermediates for intramolecular HEW reactions. Diethylphosphonoacetic Acid is an intermediate of Afatinib Dimaleate (CAS: 850140-73-7). Afatinib Dimaleate was approved by the U.S. Food and Drug Administration (FDA) in 2013 for the treatment of non-small cell lung cancer (NSCLC). Specifically, it was approved for patients presenting with metastatic NSCLC tumors which contain epidermal growth factor receptor (EGFR) exon deletions or exon 21 mutations. Afatinib Dimaleate is a covalent inhibitor of ErbB tyrosine kinases (tyk), which downregulates ErbB signaling by irreversible binding of EGFR tyk binding sites.
